Keyword: Peyronie's Disease

ABSTRACT: Introduction: Peyronie's disease (PD) is characterized by the development of fibrous plaques within the tunica albuginea, leading to penile deformity and significant psychological distress. While various surgical options exist, plaque incision or excision with grafting remains the gold standard for correcting complex or severe curvatures (>60–70°). This review evaluates the clinical outcomes, technical success, and complication rates of various autograft materials.
Historically, dermal grafts were the first autografts used but have fallen out of favor due to high rates of penile shortening (45–70%) and de novo ED (up to 66.7%). Saphenous vein grafts (SVG) demonstrate an initial success rate of ~85.6%, though long-term follow-up indicates a decline in straightness and rising ED rates (22.5%). Tunica albuginea and tunica vaginalis grafts show high technical success (90–100%) with low metabolic demand. More contemporary options, specifically fascia (lata and temporalis) and buccal mucosa grafts (BMG), show superior outcomes. Fascia grafts report technical success rates near 100% with minimal shortening. BMG demonstrates a 94.1% success rate with low de novo ED (0–10%) and rapid tissue integration.